Mitochondrial dysfunction in human pathologies.
Front Biosci
; 12: 1131-53, 2007 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-17127367
ABSTRACT
The integrity of mitochondrial function is fundamental to cell life. The cell demands for mitochondria and their complex integration into cell biology, extends far beyond the provision of ATP. It follows that disturbances of mitochondrial function lead to disruption of cell function, expressed as disease or even death. Mitochondria are major producers of free radical species and also possibly of nitric oxide, and are, at the same time, major targets for oxidative damage. In this review we consider recent developments in our knowledge of how the mitochondrial production of reactive oxygen species (ROS) plays a critical role in several major human pathologies. We will also consider recent advances in our understanding of the molecular mechanisms involved in mitochondrial ROS detoxification.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Oxidativo
/
Enfermedades Neurodegenerativas
/
Mitocondrias
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Front Biosci
Asunto de la revista:
BIOLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
España