Inhibiting transcription of chromosomal DNA using antigene RNAs.
Nucleic Acids Symp Ser (Oxf)
; (49): 367-8, 2005.
Article
en En
| MEDLINE
| ID: mdl-17150786
ABSTRACT
Transcription start sites are critical switches for converting recognition of chromosomal DNA into synthesis of RNA. We report that antigene peptide nucleic acid (agPNA) oligomers or antigene RNA (agRNA) duplexes can target transcription start sites and block gene expression. Our data suggest that chromosomal DNA within cells is readily accessible to recognition by synthetic agents. agPNAs and agRNAs will be useful tools for silencing gene expression and will provide insights into natural mechanisms for controlling transcription.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ARN Bicatenario
/
Ácidos Nucleicos de Péptidos
/
Silenciador del Gen
/
Sitio de Iniciación de la Transcripción
Límite:
Humans
Idioma:
En
Revista:
Nucleic Acids Symp Ser (Oxf)
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos