Structure-activity relationships for flow cytometric data of smaller polycyclic aromatic hydrocarbons.
SAR QSAR Environ Res
; 17(6): 597-605, 2006 Dec.
Article
en En
| MEDLINE
| ID: mdl-17162389
ABSTRACT
Using flow cytometry, select polycyclic aromatic hydrocarbons (PAHs) were evaluated for induction of apoptosis in human monocytic THP-1 cells. Based on structure, the PAHs were divided into linear and bay-region-containing compounds. Except for fluorene, the linear PAHs failed to induce apoptosis; all of the bay-region-containing PAHs induce apoptosis. The relationship that a bay-region is required to induce apoptosis is supported by results for benzo[a]pyrene (positive) and 2-methylanthracene (negative). The data for bay-region containing, four-ringed PAH compounds reveal that possessing a linear-region of more than two rings diminishes the ability of a PAH to induce apoptosis. Owing to the steric interactions of the hydrogen atoms of the methyl group and those on the ring carbons, 1-methylanthracene does not have a true bay-region. However, the methyl group substituted in the 1-position does confer a bay-like conformation, which may explain its activity in contrast to its parent derivative anthracene and its 2-postion homologue.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hidrocarburos Policíclicos Aromáticos
/
Interpretación Estadística de Datos
/
Relación Estructura-Actividad Cuantitativa
/
Citometría de Flujo
Límite:
Humans
Idioma:
En
Revista:
SAR QSAR Environ Res
Asunto de la revista:
SAUDE AMBIENTAL
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos