Gene expression and generation of CD28-CD8 T cells mediated by interleukin 15.
Exp Gerontol
; 42(5): 412-5, 2007 May.
Article
en En
| MEDLINE
| ID: mdl-17204390
ABSTRACT
Accumulation of CD28(-)CD8 T cells that are defective in response to antigenic stimulation is a hallmark of age-associated decline in T cell function. However, the underlying mechanism of this age-associated change is not fully understood. We recently analyzed the global gene expression profiles of CD8 T cell subsets from nai ve to memory (CD28(+) to CD28(-)) cells and the growth of CD28(+) and CD28(-)CD8 memory T cells in response to homeostatic cytokine interleukin 15 (IL-15). At the gene expression level, one of the most striking changes is the altered expression of some co-stimulatory receptors and various NK cell receptors in CD28(-)CD8 T cells. Furthermore, CD28(-)CD8 T cells appear to have a normal proliferation response to IL-15 in vitro. Interestingly, IL-15 is also capable of inducing stable loss of CD28 expression in actively dividing CD28(+)CD8 memory T cells. Together, these findings provide the gene expression features of CD28(-)CD8 T cells that differ from their CD28(+) counterparts and suggest a possible role of IL-15 in the increase of CD28(-)CD8 T cells that occurs with aging.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Regulación de la Expresión Génica
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Antígenos CD28
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Linfocitos T CD8-positivos
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Interleucina-15
Límite:
Humans
Idioma:
En
Revista:
Exp Gerontol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos