Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition.
Nature
; 354(6353): 453-9, 1991 Dec 12.
Article
en En
| MEDLINE
| ID: mdl-1721107
ABSTRACT
In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope sequences in the lymphocytes of these patients. Some of these viral variants are not recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets would provide a mechanism for immune escape.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T Citotóxicos
/
Infecciones por VIH
/
VIH
/
Proteína p24 del Núcleo del VIH
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Nature
Año:
1991
Tipo del documento:
Article
País de afiliación:
Reino Unido