Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily.
Clin Chem Lab Med
; 45(2): 136-42, 2007.
Article
en En
| MEDLINE
| ID: mdl-17311497
ABSTRACT
BACKGROUND:
Homocysteine is associated with age, folate and vitamin B(12). Our study investigated the functional and clinical characteristics of the elderly (aged 60-85 years) of San Teodoro, a village in Central Sicily, and evaluated associations with vitamin B(12), folate and homocysteine.METHODS:
Subjects (n=280) were examined after door-to-door recruitment using interview, physician examination and laboratory tests.RESULTS:
A total of 19.3% of the population had a low blood level of folate (<7 nmol/L) and 3.2% had low vitamin B(12) concentration (<100 pmol/L). The level of dependency, determined by the Barthel index, influenced homocysteine blood levels (p<0.0001), independent of age (p<0.0001), folate (p=0.0028) and vitamin B(12) (p=0.0165). Homocysteine was significantly associated with stroke (p=0.0027) and peripheral arterial vascular disease (p=0.0001), but not with myocardial infarction, angina pectoris, venous thrombosis or cancer. Vitamin B(12) was lower in myocardial infarction and higher in diabetes and venous thrombosis compared to the other diseases.CONCLUSIONS:
The prevalence of deficits in folate and vitamin B(12) was paradoxically high in the mountainous northeastern area of Sicily. Our study also underlines the association of homocysteine with dependency of the elderly and with stroke and peripheral arteriopathy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vitamina B 12
/
Envejecimiento
/
Ácido Fólico
/
Homocisteína
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Humans
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Clin Chem Lab Med
Asunto de la revista:
QUIMICA CLINICA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2007
Tipo del documento:
Article
País de afiliación:
Italia