Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
Bioorg Med Chem Lett
; 17(9): 2540-4, 2007 May 01.
Article
en En
| MEDLINE
| ID: mdl-17317165
ABSTRACT
A series of substituted 2-aminobenzothiazole compounds have been synthesized and evaluated as nitric oxide synthase (NOS) inhibitors. Compound 14 shows activity in the nM range and is selective for the human neuronal NOS isoform. We have also evaluated the compounds against the rat NOS isoforms. For some of the compounds, there are significant differences in NOS inhibitory activities between the human and rat enzymes. For example, compound 10b has nM activity against the rat nNOS while low microM activity against the human nNOS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiazoles
/
Química Farmacéutica
/
Inhibidores Enzimáticos
/
Benzotiazoles
/
Óxido Nítrico Sintasa de Tipo I
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2007
Tipo del documento:
Article