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Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin.
Schick, B A; Laaksonen, R; Frohlich, J J; Päivä, H; Lehtimäki, T; Humphries, K H; Côté, H C F.
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  • Schick BA; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada, and Research Unit, Tampere University Hospital, Finland.
Clin Pharmacol Ther ; 81(5): 650-3, 2007 May.
Article en En | MEDLINE | ID: mdl-17329991
Statins are generally well tolerated, but can cause myopathy and have been associated with mitochondrial abnormalities. The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published clinical trial of high-dose simvastatin or atorvastatin versus placebo.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN Mitocondrial / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Simvastatina / Mitocondrias Musculares Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Pharmacol Ther Año: 2007 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN Mitocondrial / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Simvastatina / Mitocondrias Musculares Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Pharmacol Ther Año: 2007 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos