Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin.
Clin Pharmacol Ther
; 81(5): 650-3, 2007 May.
Article
en En
| MEDLINE
| ID: mdl-17329991
Statins are generally well tolerated, but can cause myopathy and have been associated with mitochondrial abnormalities. The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published clinical trial of high-dose simvastatin or atorvastatin versus placebo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN Mitocondrial
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Simvastatina
/
Mitocondrias Musculares
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Pharmacol Ther
Año:
2007
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
Estados Unidos