Detection of growth hormone abuse in sport.
Growth Horm IGF Res
; 17(3): 220-6, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17339122
ABSTRACT
OBJECTIVE:
To develop a test for GH abuse in sport.DESIGN:
A double blind placebo controlled study of one month's GH administration to 102 healthy non-competing but trained subjects. Blood levels of nine markers of GH action were measured throughout the study and for 56 days after cessation of GH administration. Blood samples were also taken from 813 elite athletes both in and out of competition.RESULTS:
GH caused a significant change in the nine measured blood markers. Men were more sensitive to the effects of GH than women. IGF-I and N-terminal extension peptide of procollagen type III were selected to construct formulae which gave optimal discrimination between the GH and placebo groups. Adjustments were made to account for the fall in IGF-I and P-III-P with age and the altered distribution seen in elite athletes. Using a cut-off specificity of 110,000 these formulae would allow the detection of up to 86% of men and 60% of women abusing GH at the doses used in this study.CONCLUSIONS:
We report a methodology that will allow the detection of GH abuse. This will provide the basis of a robust and enforceable test identifying those who are already cheating and provide a deterrent to those who may be tempted to do so.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Factor I del Crecimiento Similar a la Insulina
/
Hormona del Crecimiento
/
Procolágeno
/
Trastornos Relacionados con Sustancias
/
Doping en los Deportes
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Growth Horm IGF Res
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Reino Unido