Heterogeneity in response to asthma medications.
Curr Opin Allergy Clin Immunol
; 7(2): 185-9, 2007 Apr.
Article
en En
| MEDLINE
| ID: mdl-17351474
ABSTRACT
PURPOSE OF REVIEW Evidence for the heterogeneity of response to asthma medications including inhaled corticosteroids and leukotriene receptor antagonists is mounting. beta2-Adrenoceptor gene polymorphisms may contribute to asthma responsiveness to short- and long-acting beta2-agonists. This review examines recent articles describing variability in response to inhaled corticosteroids, leukotriene receptor antagonists and short-acting beta2-agonists specifically in pediatric persistent asthmatics. RECENT FINDINGS:
In the late 1990's, differences in the response to a leukotriene receptor antagonist and an inhaled corticosteroid in adults with moderate persistent asthma were first described. Subsequently, similar findings have recently been elucidated in children with mild to moderate persistent asthma. The variability in response to these two classes of control medicines now appears to encompass all ages with persistent asthma. In general, despite the variability in response to these medications, both resulted in improved clinical and physiologic control measures.SUMMARY:
Childhood asthma is a complex disease with numerous clinical phenotypes that contribute to response variability to asthma medications.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asma
Límite:
Adolescent
/
Child
/
Humans
Idioma:
En
Revista:
Curr Opin Allergy Clin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos