Stereoselective synthesis of L-threo-sphingosine, L-threo-sphinganine, D-threo-sphingosine, and D-threo-sphinganine via oxazoline formation and olefin cross-metathesis; potent protein kinase C inhibitor analogues.
Arch Pharm Res
; 30(2): 167-71, 2007 Feb.
Article
en En
| MEDLINE
| ID: mdl-17366737
ABSTRACT
In this study, we explored a convenient and concise route for synthesis of L-threo-sphingosine, D-threo-sphingosine, L-threo-sphinganine and D-threo-sphinganine from commercially available L- or D-serine. The key steps are the simple preparation of trans-oxazoline and intermolecular olefin cross metathesis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxazoles
/
Esfingosina
/
Proteína Quinasa C
/
Inhibidores de Proteínas Quinasas
/
Alquenos
Idioma:
En
Revista:
Arch Pharm Res
Año:
2007
Tipo del documento:
Article