[Clinicopathologic study of subependymal giant cell astrocytoma].
Zhonghua Bing Li Xue Za Zhi
; 35(11): 656-9, 2006 Nov.
Article
en Zh
| MEDLINE
| ID: mdl-17374208
ABSTRACT
OBJECTIVE:
To study the clinicopathologic features of subependymal giant cell astrocytoma.METHODS:
The clinical and pathologic characteristics of 18 cases of subependymal giant cell astrocytoma were retrospectively analyzed.RESULTS:
Amongst the 18 cases studied, there was a male predominance (male-to-female ratio = 21). The age of patients ranged from 7 to 54 years (mean age = 18.2 years). The tumor often occurred in the lateral ventricles (16/18, 88.9%). Most patients presented with headache and vomiting (11/18, 61.1%), followed by visual disturbance (3/18, 16.7%). Eleven patients (61.1%) had clinical features of tuberous sclerosis, usually in the form of facial angiofibroma (8/18, 44.4%). Computerized tomography was performed in 10 cases, in which 7 cases were of high density and 5 cases showed contrast enhancement. MRI revealed isointense mass lesion on T1WI (7/11, 63.6%), highly intense lesion on T2WI (10/11, 90.9%) and contrast enhancement in some cases (9/11, 81.8%). Four patients had follow-up information available and all of them were alive from 1 to 5 years (mean = 3.5 years). Histologically, there were bundles of spindle cells mixed with clusters of gemistocytes and ganglion-like cells. The spindle cells showed immunoreactivity for glial fibrillary acidic protein (18/18, 100%), while the gemistocytes and ganglion-like cells expressed synaptophysin (14/18, 77.8%). Most of the cases (16/18, 88.9%) had MIB-1 index
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Astrocitoma
/
Neoplasias del Ventrículo Cerebral
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Bing Li Xue Za Zhi
Año:
2006
Tipo del documento:
Article
País de afiliación:
China