The Janus faces of botulinum neurotoxin: sensational medicine and deadly biological weapon.
J Neurosci Res
; 85(6): 1149-58, 2007 May 01.
Article
en En
| MEDLINE
| ID: mdl-17387703
ABSTRACT
The botulinum neurotoxins are the most dangerous toxins known (BoNTs serotypes A-G) and induce profound flaccid neuromuscular paralysis by blocking nerve-muscle communication. Poisoned motoneurons react by emitting a sprouting network known to establish novel functional synapses with the abutting muscle fiber. Understanding how our motoneurons are capable of bypassing such transmission blockade, thereby overcoming paralysis, by an astonishing display of plasticity is one of the research goals that have numerous therapeutic ramifications. This Mini-Review aims at giving a brief update on the recent discoveries regarding the molecular mechanism of botulinum toxins intoxication. Curing botulism still is a challenge once the toxin has found his way inside motoneurons. In view of the potential use of botulinum toxins as biological weapon, more research is needed to find efficient ways of curing this disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Toxinas Botulínicas
/
Síndromes de Neurotoxicidad
/
Neurotoxinas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Neurosci Res
Año:
2007
Tipo del documento:
Article
País de afiliación:
Australia