Caffeine and 35% carbon dioxide challenge tests in panic disorder.
Hum Psychopharmacol
; 22(4): 231-40, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17407170
ABSTRACT
Our aim was to compare the demographic and clinical features of panic disorder (PD) patients with agoraphobia-DSM-IV-who had a panic attack after both an oral caffeine and the 35% carbon dioxide (CO2) challenge tests (responsive group) and compare them with PD patients who did not have a panic attack after both tests (non-responsive group). We examined 83 PD patients submitted to a 35% CO2 test and to an oral caffeine (480 mg) intake within 1 week interval. A panic attack was induced in 51 (61.4%) patients during the CO2 test (chi2=31.67, df=1, p<0.001) and in 38 (45.8%) patients during the caffeine test (chi2=18.28, df=1, p=0.023). All patients who had a panic attack during the caffeine test also had a panic attack during the CO2 test (n=38)-responsive group. The responsive had more (chi2=24.55, df=1, p=0.008) respiratory PD subtype, disorder started earlier (Mann-Whitney, p<0.001) had a higher familial prevalence of PD (chi2=20.34, df=1, p=0.019), less previous alcohol abuse (chi2=23.42, df=1, p<0.001), and had more previous depressive episodes (chi2=27.35, df=1, p<0.001). Our data suggest that there is an association between respiratory PD subtype and hyperreactivity to challenge tests CO2 and oral caffeine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cafeína
/
Dióxido de Carbono
/
Trastorno de Pánico
/
Agorafobia
/
Estimulantes del Sistema Nervioso Central
Tipo de estudio:
Clinical_trials
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hum Psychopharmacol
Asunto de la revista:
PSICOFARMACOLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Brasil