Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells.
J Biol Chem
; 282(22): 16631-43, 2007 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-17416589
ABSTRACT
Various cellular signals initiate calcium entry into cells, and there is evidence that lipid rafts and caveolae may concentrate proteins that regulate transmembrane calcium fluxes. Here, using mice deficient in caveolin-1 (Cav-1) and Cav-1 knock-out reconstituted with endothelium-specific Cav-1, we show that Cav-1 is essential for calcium entry in endothelial cells and governs the localization and protein-protein interactions between transient receptor channels C4 and C1. Thus, Cav-1 is required for calcium entry in vascular endothelial cells and perhaps other specialized cell types containing caveolae.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Calcio
/
Caveolas
/
Células Endoteliales
/
Caveolina 1
/
Canales Catiónicos TRPC
Límite:
Animals
Idioma:
En
Revista:
J Biol Chem
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos