Effect of 5-HT(2) receptor blockade on cadmium-induced acute toxicity.
Dig Dis Sci
; 52(9): 2351-8, 2007 Sep.
Article
en En
| MEDLINE
| ID: mdl-17420952
ABSTRACT
The protective effect of 5-HT(2) receptor blockade with ketanserin or ritanserin against cadmium liver injury was investigated. Male Wistar rats were injected intraperitoneally with a sublethal dose of cadmium (3.5 mg/kg body weight). Rats were treated with normal saline (group I), ketanserin (3 mg/kg body weight; group II), or ritanserin (3 mg/kg body weight; group III) 2 hr prior and 4 hr after cadmium administration and killed at different time points. Hematoxylin/eosin-stained liver sections were assessed for necrosis, apoptosis, peliosis, mitoses, and inflammatory infiltration. Apoptosis was also quantified by the TUNEL assay. Nonparenchymal liver cells and activated Kupffer cells were identified histochemically. Necrosis, hepatocyte apoptosis, nonparenchymal cell apoptosis, and macroscopic and microscopic peliosis were markedly reduced or minimized in ketanserin- or ritanserin-treated rats. The observed protective effect was almost identical for both ketanserin and ritanserin administration. 5-HT(2) receptor blockade exerts a protective effect against acute cadmium-induced hepatotoxicity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antagonistas de la Serotonina
/
Ketanserina
/
Ritanserina
/
Fallo Hepático Agudo
/
Antagonistas del Receptor de Serotonina 5-HT2
Límite:
Animals
Idioma:
En
Revista:
Dig Dis Sci
Año:
2007
Tipo del documento:
Article
País de afiliación:
Grecia