Factors associated with withdrawal bleeding after administration of oral micronized progesterone in women with secondary amenorrhea.
Fertil Steril
; 56(6): 1040-7, 1991 Dec.
Article
en En
| MEDLINE
| ID: mdl-1743319
ABSTRACT
OBJECTIVE:
To compare two dosages of oral micronized progesterone (P) and placebo for withdrawal bleeding and side effects.DESIGN:
Prospective, randomized, double-blind.SETTING:
Academic institution.PARTICIPANTS:
Out of 190 screened with oligomenorrhea/amenorrhea, 60 who qualified completed the study.INTERVENTIONS:
A 10-day course of (1) oral micronized P 300 mg, (2) oral micronized P 200 mg, or (3) placebo. MAIN OUTCOMEMEASURES:
Withdrawal bleeding, side effects, and changes in lipids. Endogenous estradiol (E2) concentrations at baseline and P concentrations during treatment were correlated with bleeding response.RESULTS:
Withdrawal bleeding occurred in 90% of women taking 300 mg, 58% of women taking 200 mg, and 29% of women taking placebo (P less than 0.0002 for 300 mg versus placebo). Side effects occurred similarly among the groups (P = not significant). Lipid concentrations were unchanged. Endogenous E2 and treatment P concentrations were of limited predictive value for withdrawal bleeding.CONCLUSIONS:
Progesterone 300 mg induced significantly more withdrawal bleeding than placebo, with similar side effects. Bleeding response cannot be predicted reliably from E2 and P concentrations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Progesterona
/
Hemorragia Uterina
/
Amenorrea
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Fertil Steril
Año:
1991
Tipo del documento:
Article