Sentinel node biopsy for breast cancer larger than 3 cm in diameter.
Br J Surg
; 94(8): 948-51, 2007 Aug.
Article
en En
| MEDLINE
| ID: mdl-17436338
ABSTRACT
BACKGROUND:
Sentinel node biopsy (SNB) is a standard staging procedure in early breast cancer. Its suitability for larger tumours has been questioned. This study evaluated the reliability of SNB in women with invasive breast cancer larger than 3 cm in diameter who were clinically axillary node negative.METHODS:
Some 109 women with a tumour larger than 3 cm on pathological analysis were identified from the Swedish prospective SNB database. They were included if a completion axillary clearance was planned, regardless of SNB results.RESULTS:
The sentinel node detection rate was 103 (94.5 per cent) of 109. The overall false-negative rate was eight (13 per cent) of 64. Although a preoperative diagnosis of multifocal tumour was an exclusion criterion, 16 such cases were revealed on postoperative pathological examination. The false-negative rate in this subgroup was higher than that in women with a unifocal tumour (four (31 per cent) of 13 versus four (8 per cent) of 51; P = 0.012). No other significant predictors of a false-negative sentinel node biopsy were identified.CONCLUSION:
SNB is feasible in patients with unifocal breast tumours larger than 3 cm. When large tumour size coincides with multifocality, however, the false-negative rate seems to be increased and a completion axillary clearance should be considered even if the SNB is negative.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mama
/
Neoplasias de la Mama
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Biopsia del Ganglio Linfático Centinela
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Br J Surg
Año:
2007
Tipo del documento:
Article
País de afiliación:
Suecia