DNA damage and cellular death in oral mucosa cells of children who have undergone panoramic dental radiography.
Pediatr Radiol
; 37(6): 561-5, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17453188
ABSTRACT
BACKGROUND:
Despite wide use as a diagnostic tool in medical and dental practice, radiography can induce cytotoxic effects and genetic damage.OBJECTIVE:
To evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells taken from healthy children following exposure to radiation during dental radiography. MATERIALS ANDMETHODS:
A total of 17 children who had undergone panoramic dental radiography were included.RESULTS:
We found no statistically significant differences (P > 0.05) between micronucleated oral mucosa cells in children before and after exposure to radiation. On the other hand, radiation did cause other nuclear alterations closely related to cytotoxicity including karyorrhexis, pyknosis and karyolysis.CONCLUSION:
Taken together, these results indicate that panoramic dental radiography might not induce chromosomal damage, but may be cytotoxic. Overall, the results reinforce the importance of evaluating the health side effects of radiography and contribute to the micronucleus database, which will improve our understanding and practice of this methodology in children.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Radiografía Panorámica
/
Núcleo Celular
/
Mucosa Bucal
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Radiol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Brasil