Acute vs chronic effects of l-dopa on bladder function in patients with mild Parkinson disease.
Neurology
; 68(18): 1455-9, 2007 May 01.
Article
en En
| MEDLINE
| ID: mdl-17470746
ABSTRACT
OBJECTIVE:
To compare acute and chronic effects of l-dopa on bladder function in levodopa-naive Parkinson disease (PD) patients who had urinary urgency.METHODS:
We evaluated 26 l-dopa-naive PD patients at a university-based PD center with a first urodynamic session with a double examination in the off treatment condition and 1 hour after acute challenge with carbidopa/l-dopa 50/200 mg; then, a chronic l-dopa monotherapy was administered (mean dose 300 +/- 150 mg). Two months later, patients underwent a second urodynamic session with a single evaluation 1 hour after the acute carbidopa/l-dopa challenge.RESULTS:
The first acute l-dopa challenge significantly worsened bladder overactivity (neurogenic overactive detrusor contractions threshold [NDOC-t; 32% of worsening] and bladder capacity [BC; 22% of worsening]); on the contrary, l-dopa challenge during chronic administration ameliorated the first sensation of bladder filling (FS; 120% of improvement), NDOCT-t (93% improvement), and BC (33% of improvement) vs the values obtained with acute administration. An 86% significant improvement of FS in comparison with the basal value was observed.CONCLUSIONS:
The acute and chronic l-dopa effects may be due to the different synaptic concentrations or to the activation of postsynaptic mechanisms obtained by chronic administration.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Vejiga Urinaria Neurogénica
/
Levodopa
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Año:
2007
Tipo del documento:
Article
País de afiliación:
Italia