Rutin in rat liver ischemia/reperfusion injury: effect on DDAH/NOS pathway.
Microsurgery
; 27(4): 245-51, 2007.
Article
en En
| MEDLINE
| ID: mdl-17477412
ABSTRACT
Nitric oxide (NO) plays a key role in the relationship between microcirculatory disorders and I/R injuries. Our results demonstrated a significant modification in the hepatic function of I/R rats compared with the control group; treatment with rutin reported hepatic damage markers to control value. Levels of plasmatic and hepatic thiol groups decreased in the I/R untreated group, and this decrease was inhibited by rutin treatment. In addition, we observed an increase in the iNOS expression in I/R group compared with control and rutin administration attenuated this increase; in post-ischemic reperfused rutin-treated rats there was a significant increase in eNOS expression compared with the I/R untreated group. In the same experimental conditions an increase in DDAH 1 expression was observed in I/R group only; rutin treatment also counteracted this increased expression. These data suggest that rutin treatment could be useful for preventing oxidative damage associated with hepatic post-ischemic reperfusion injury.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rutina
/
Daño por Reperfusión
/
Óxido Nítrico Sintasa
/
Amidohidrolasas
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Microsurgery
Año:
2007
Tipo del documento:
Article
País de afiliación:
Italia