Grade migration in prostate cancer: an analysis using the Surveillance, Epidemiology, and End Results registry.
Prostate Cancer Prostatic Dis
; 10(4): 347-51, 2007.
Article
en En
| MEDLINE
| ID: mdl-17505529
ABSTRACT
To utilize the Surveillance, Epidemiology, and End Results (SEER) registry to examine trends in grade assignment. Data from 411 325 patients from 1984 to 2003 were analyzed for grade migration and for cause-specific survival (CSS) as a function of grade. There has been a significant grade migration during the study period (P<0.001), principally from well-differentiated (WD) to moderately differentiated (MD) disease. Five-year CSS of MD and WD patients have converged, suggesting a decreasing role of grade as a prognostic factor. A grade migration from WD to MD assignment has occurred, suggesting that prognostic categorizations based on grade across eras may be difficult to interpret.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Sistema de Registros
/
Programa de VERF
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Límite:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Prostate Cancer Prostatic Dis
Asunto de la revista:
ENDOCRINOLOGIA
/
NEOPLASIAS
/
UROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos