Sevoflurane: are there differences in products?
Anesth Analg
; 104(6): 1447-51, table of contents, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17513639
ABSTRACT
Sevoflurane is currently available in the United States from two manufacturers Ultane (Abbott Laboratories, Inc.) and a generic product, Sevoflurane Inhalation Anesthetic (Baxter Healthcare Corp.). These products are rated therapeutically equivalent by the Food and Drug Administration, but there are some differences. Ultane is made in a single-step synthetic process and generic sevoflurane is manufactured using a three-step process. Ultane contains >300 ppm water and generic sevoflurane contains < or =130 ppm water. Ultane is supplied in a plastic polyethylene naphthalate polymer bottle, while generic sevoflurane is supplied in lacquer-lined aluminum bottles. The manufacturing processes and impurities, sevoflurane degradation resulting from Lewis acid reactions, and suitability of nonglass containers for sevoflurane are discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anestésicos por Inhalación
/
Industria Farmacéutica
/
Éteres Metílicos
Idioma:
En
Revista:
Anesth Analg
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos