Children with human immunodeficiency virus infection admitted to a paediatric intensive care unit in South Africa.
J Trop Pediatr
; 53(4): 270-3, 2007 Aug.
Article
en En
| MEDLINE
| ID: mdl-17526510
ABSTRACT
BACKGROUND:
Early data regarding the outcome of human immunodeficiency virus (HIV)-infected children in paediatric intensive care units (PICU) suggested mortality as high as 100%. Recent studies report mortality of 38%. Survival depends on the indication for admission.OBJECTIVES:
To describe the prevalence, duration of stay, and outcome of HIV-infected patients in a single PICU over a 1-year period. Additional objectives included describing the indications for admission as well as the clinical and laboratory characteristics of HIV-infected infants and children requiring PICU admission.METHOD:
Retrospective chart review of all children with serological proof of HIV admitted to PICU at Tygerberg Children's Hospital from 1 January to 31 December 2003.RESULTS:
Of the 465 patients admitted, 47 (10%) were HIV-infected. For HIV-infected children the median age on admission was 4 months. The median duration of stay was 6 days, significantly longer than for the non-HIV group (p = 0.0001). Fifty-seven percent had advanced clinical and immunological disease. Seventeen died in PICU and four shortly afterwards, poor PICU outcome was significantly associated with HIV status (p = 0.001). Lower total lymphocyte count (p = 0.004) and higher gamma globulin level (p = 0.04) were paradoxically the only findings significantly associated with survival. Acute respiratory failure (ARF) accounted for 76% of admissions, including Pneumocystis jiroveci in 38%. Fifty-one percent had evidence of cytomegalovirus infection.CONCLUSIONS:
HIV-infected children requiring PICU can survive despite the lack of availability of antiretroviral therapy.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neumonía por Pneumocystis
/
Síndrome de Dificultad Respiratoria
/
Unidades de Cuidado Intensivo Pediátrico
/
Infecciones por VIH
/
Infecciones por Citomegalovirus
/
Pneumocystis carinii
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Humans
/
Infant
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Trop Pediatr
Año:
2007
Tipo del documento:
Article
País de afiliación:
Sudáfrica