BCG-osis and tuberculosis in a child with chronic granulomatous disease.
J Allergy Clin Immunol
; 120(1): 32-8, 2007 Jul.
Article
en En
| MEDLINE
| ID: mdl-17544093
ABSTRACT
A few known primary immunodeficiencies confer predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG vaccines (regional disease, known as BCG-itis, or disseminated disease, known as BCG-osis), or more virulent mycobacteria, such as Mycobacterium tuberculosis (pulmonary and disseminated tuberculosis). We investigated the clinical and genetic features of a 12-year-old boy with both recurrent BCG-osis and disseminated tuberculosis. The patient's phagocytic cells produced no O(2)(-). A hemizygous splice mutation was found in intron 5 of CYBB, leading to a diagnosis of X-linked chronic granulomatous disease. Chronic granulomatous disease should be suspected in all children with BCG-osis, even in the absence of nonmycobacterial infectious diseases, and in selected children with recurrent BCG-itis or severe tuberculosis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Vacuna BCG
/
Enfermedad Granulomatosa Crónica
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
J Allergy Clin Immunol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia