Total plasmatic homocysteine and von Willebrand factor in experimental diabetes mellitus.
Arq Bras Cardiol
; 88(4): 424-9, 2007 Apr.
Article
en En, Pt
| MEDLINE
| ID: mdl-17546272
ABSTRACT
OBJECTIVES:
To determine the plasma homocysteine and von Willebrand factor levels as markers of endothelial dysfunction in rats with diabetes mellitus induced by streptozotocin.METHODS:
Thirty-five adult male rats (Rattus norvegicus albinus) (weight between 180-200 g) were randomized into three groups control group (n=10), which received no drugs or vehicles; sham group (n=10), which received streptozotocin solution; and diabetic group (n=15), which received streptozotocin. Eight weeks after diabetes mellitus induction, the animals were weighed and anesthesized; blood samples were collected from abdominal aorta for plasma total homocysteine, von Willebrand factor and glucose levels.RESULTS:
The experimental model was reproducible in 100% of animals. The mean plasma homocysteine levels were 7.9 micromol/l (control), 8.6 micromol/l (sham) and 6.1 micromol/l (diabetic), with difference among the groups (p<0.01). Multiple comparison analysis among the groups showed that values in the diabetic group were lower than in the sham group (p<0.01). The mean von Willebrand factor values were 0.15 U/l (control), 0.16 U/l (sham) and 0.18 U/l (diabetic), with difference among the groups (p=0.03). The mean value was higher in the diabetic group than in the control group (p<0.05). Correlation between homocysteine and von Willebrand factor was not observed in the diabetic group.CONCLUSION:
Reduced homocysteine levels and increased von Willebrand factor levels were observed in diabetes mellitus induced by streptozotocin; nevertheless, there were no correlations between them and with final glucose levels.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor de von Willebrand
/
Diabetes Mellitus Experimental
/
Homocisteína
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
/
Pt
Revista:
Arq Bras Cardiol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
BR
/
BRASIL
/
BRASILE
/
BRAZIL
/
BRESIL