[Modulative effect of zhenqing recipe on expressions of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in experimental type 2 diabetic rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi
; 26 Suppl: 72-6, 2006 Jun.
Article
en Zh
| MEDLINE
| ID: mdl-17569353
ABSTRACT
OBJECTIVE:
To explore the effect of Zhenqing Recipe (ZQR) on renal structure and expressions of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in experimental type 2 diabetic rats.METHODS:
The rat models of type 2 diabetic were set up by intraperitoneally giving small-dose streptozotocin (STZ) after fed with high carbohydrate and high fat diets for one month. The model rats were randomly divided into the model group,the high and low dose ZQR-treated groups,and the enalapril-treated group; a normal control group was also established. The course of treatment continued 8 weeks. The expressions of MMP-9, TIMP-1, and fibronectin (FN) in renal tissues were detected by immunohistochemistry. The morphological changes of glomeruli and renal tubules were checked by microscopy.RESULTS:
Compared with the normal control group, the expression of TIMP-1 and FN increased and MMP-9 decreased in the model group; the treated groups could decrease the expressions of TIMP-1 and FN, and increase the expression of MMP-9, especially the high-dose ZQR group had the best effect. The morphological changes of renal tubules and glomerulus in the treated groups were improved better as compared with the model group.CONCLUSION:
The protective effect of ZQR on renal structure may be achieved by modulating the expressions of MMP-1 and TIMP-1.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
/
Inhibidor Tisular de Metaloproteinasa-1
/
Sustancias Protectoras
/
Metaloproteinasa 9 de la Matriz
/
Diabetes Mellitus Experimental
/
Diabetes Mellitus Tipo 2
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Xi Yi Jie He Za Zhi
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2006
Tipo del documento:
Article