Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins.
FEBS Lett
; 581(17): 3149-56, 2007 Jul 10.
Article
en En
| MEDLINE
| ID: mdl-17572408
ABSTRACT
We have identified a novel vertebrate-specific gene by applying a Differential Display method on two distinct subtypes of pituitary melanotropes showing divergent secretory phenotypes of hypo- and hypersecretion. A paralogue of this gene was also identified. The existence of a long coiled-coil domain and a C-terminal transmembrane domain in the sequences, together with the Golgi distribution of the proteins in transfected cells, suggest that they can be considered as new members of the golgin family of proteins. Both genes were primarily expressed in (neuro)endocrine tissues in vertebrates thus supporting a role for these proteins in the regulated secretory pathway.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Melanotrofos
/
Proteínas de la Membrana
/
Sistemas Neurosecretores
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2007
Tipo del documento:
Article
País de afiliación:
España