Chiral separation of sympathomimetics and beta-blockers by ligand-exchange CE using Cu(II) complexes of L-tartaric acid and L-threonine as chiral selectors.
Electrophoresis
; 28(15): 2675-82, 2007 Aug.
Article
en En
| MEDLINE
| ID: mdl-17597468
ABSTRACT
This paper deals with the use of Cu(II) complexes of L-tartaric acid or L-threonine as selectors for the chiral separation of drugs containing amino alcohol structure by ligand-exchange CE. Using Cu(II) ions as a complexing agent, a series of sympathomimetics and beta-blockers were resolved. It was found that the resolution strongly depends on selector concentration and pH. The optimum pH for complexation was 12.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Simpatomiméticos
/
Antagonistas Adrenérgicos beta
/
Electroforesis Capilar
/
Amino Alcoholes
Idioma:
En
Revista:
Electrophoresis
Año:
2007
Tipo del documento:
Article
País de afiliación:
Austria