[Two types of NP-NP associations in influenza virus-infected cells].
Vopr Virusol
; 52(3): 9-12, 2007.
Article
en Ru
| MEDLINE
| ID: mdl-17601043
ABSTRACT
Two types of NP-NP associations are shown to form in the influenza virus-infected cells. Early NP synthesis gives rise to NP associations stabilized by relatively weak bonds. These structures are designed as NP multimers. The high protease- and heat-sensitivities allow NP-multimers to be regarded as incompletely folded proteins. Post-translationally, NP-multimers transform to compact NP associations (NP oligomers) that are relatively highly heat-and protease-resistant. The NP-multimers untransformed to the folded compact NP-oligomers accumulate in the cells and partially degraded. Whether both types of NP-NP associations may be of significance is under discussion.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Procesamiento Proteico-Postraduccional
/
Proteínas del Núcleo Viral
/
Proteínas de Unión al ARN
/
Pliegue de Proteína
/
Infecciones por Orthomyxoviridae
/
Alphainfluenzavirus
/
Nucleoproteínas
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
Ru
Revista:
Vopr Virusol
Año:
2007
Tipo del documento:
Article