Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients.
Cell Mol Neurobiol
; 27(6): 695-700, 2007 Sep.
Article
en En
| MEDLINE
| ID: mdl-17619138
ABSTRACT
As with chromosomal DNA, the mitochondrial DNA (mtDNA) can contain mutations that are highly pathogenic . In fact, many diseases of the central nervous system are known to be caused by mutations in mtDNA. Dysfunction of the mitochondrial Respiratory Chain (RC) has been shown in patients with neurological disease including Alzheimer's disease (AD), Parkinson's disease (PD) and Multiple sclerosis (MS). MS is a demyelinating disease of central nervous system characterized by morphological hallmarks of inflammation, demyelination and axonal loss. Considering this importance, we decided to investigate several highly mutative parts of mtDNA for point mutations as MT-LTI (tRNA(Leucine1(UUA/G))), MT-NDI (NADH Dehydrogenase subunit 1), MT-COII (Cytochrome c oxidase subunit II), MT-TK (tRNA(Lysine)), MT-ATP8 (ATP synthase subunit F0 8) and MT-ATP6 (ATP synthase subunit F0 6) in 20 Iranian MS patients and 80 age-matched control subjects by PCR and automated DNA sequencing to evaluate any probable point mutations. Our results revealed that 15 (75%) out of 20 MS patients had point mutations. Some of point mutations were newly found in this study. This study suggested that point mutation occurred in mtDNA might be involved in pathogenesis of MS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ARN de Transferencia de Leucina
/
ATPasas de Translocación de Protón Mitocondriales
/
Esclerosis Múltiple
/
NADH Deshidrogenasa
Tipo de estudio:
Observational_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Cell Mol Neurobiol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Irán