[Effects of acupuncture on granulocyte apoptosis and expressions of apoptosis-associated genes in the ovary of perimenopausal rats].
Zhongguo Zhen Jiu
; 27(5): 357-61, 2007 May.
Article
en Zh
| MEDLINE
| ID: mdl-17645259
ABSTRACT
OBJECTIVE:
To explore the mechanism of acupuncture for treatment of perimenopausal syndrome.METHODS:
The rats of perimenopausal syndrome were randomly divided into 3 groups, including an acupuncture group treated with acupuncture, a medication group with Gengnian'an, and a perimenopausal control group, with young rats used for a control group. Granulocyte apoptosis and expressions of Bcl-2 and Fas proteins in the ovary of the rat were detected.RESULTS:
Granulocyte apoptosis increased significantly (P < 0.01), expression of Bl-2 proteins decreased significantly (P < 0.01) and expression of Fas proteins increased significantly (P < 0.01) in the ovary of perimenopausal rats as compared with the young rats; after acupuncture treatment, granulocyte apoptosis decreased significantly (P < 0.05), expression of Bel-2 proteins increased significantly (P < 0.05) and expression of Fas proteins decreased significantly (P < 0.01); after treatment of Gengnian'an, granulocyte apoptosis did not significantly change (P > 0.05), expression of Bcl-2 prteins increased significantly (P < 0.05) and expression of Fas proteins decreased significantly (P < 0.01).CONCLUSION:
Acupuncture can inhibit granulocyte apoptosis, up-regulate expression of Bcl-2 proteins and down-regulate expression of Fas proteins in the ovary of the perimenopausal rat.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ovario
/
Terapia por Acupuntura
/
Apoptosis
/
Receptor fas
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Granulocitos
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhen Jiu
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2007
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
CHINA
/
CN
/
REPUBLIC OF CHINA