Neuronal degeneration in the striatum of the groggy rat: a new mutant with a movement disorder.
Experientia
; 47(11-12): 1215-8, 1991 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-1765133
ABSTRACT
A new mutation displaying abnormal movement was obtained in the progeny of a female Wistar rat which had been given 10 mg/kg methylnitrosourea at an early stage of the gestational period. Genetic studies revealed that the character is inherited by an autosomal single recessive gene, and we designated this mutation groggy (gene symbol gr). The abnormal movement of the groggy rat was first apparent around postnatal day 15, while the histological studies revealed the appearance of numerous necrotic neurons in the striatum of the groggy rat on postnatal days 60 and 120.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ratas Mutantes
/
Cuerpo Estriado
/
Trastornos del Movimiento
Límite:
Animals
Idioma:
En
Revista:
Experientia
Año:
1991
Tipo del documento:
Article
País de afiliación:
Japón