Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana.
Fitoterapia
; 79(1): 1-5, 2008 Jan.
Article
en En
| MEDLINE
| ID: mdl-17683879
ABSTRACT
Dehydroleucodine (DhL), a sesquiterpene lactone obtained from Artemisia douglasiana, was screened for antidiarrheal effects. DhL inhibited castor oil-induced diarrhea in mice by judged by a decrease in the number of wet faeces in the DhL-treatment groups. DhL significantly reduced intestinal transit in mice. Yohimbine and phentolamine counteracted the inhibitory effect of DhL. It is suggested that alpha2-adrenergic receptors mediate the effect of DhL in intestinal motility. DhL reduced also intraluminal accumulation of fluid. Thus, the antidiarrheal activity of DhL is possibly related, at least in part, to its inhibitory action against gastrointestinal motility and the inhibition of enteropooling property.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
/
Fármacos Gastrointestinales
/
Tránsito Gastrointestinal
/
Extractos Vegetales
/
Artemisia
/
Diarrea
/
Lactonas
/
Fitoterapia
Límite:
Animals
Idioma:
En
Revista:
Fitoterapia
Año:
2008
Tipo del documento:
Article
País de afiliación:
Argentina