Combined pituitary hormone deficiency and PROP-1 mutation in two siblings: a distinct MR imaging pattern of pituitary enlargement.
AJNR Am J Neuroradiol
; 28(7): 1369-70, 2007 Aug.
Article
en En
| MEDLINE
| ID: mdl-17698542
ABSTRACT
Mutations of the PROP-1 gene are the most frequent genetic defect in patients with combined pituitary hormone insufficiency. We present the cases of 2 siblings with PROP-1 mutations whom we observed longitudinally. Their initial pituitary MR imaging examinations showed identical findings:
an enlarged adenohypophysis, with striking hypointensity on T2-weighted images and slight hyperintensity on T1-weighted images. In one of the children, the follow-up MR imaging obtained 3 years after hormonal replacement revealed a decrease in the size of the anterior pituitary lobe.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipófisis
/
Imagen por Resonancia Magnética
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Proteínas de Homeodominio
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Hipopituitarismo
Límite:
Child
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Female
/
Humans
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Male
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Brasil