Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy.
Pharmacogenomics J
; 8(2): 113-6, 2008 Apr.
Article
en En
| MEDLINE
| ID: mdl-17700596
ABSTRACT
Several lines of evidence suggest that catechol-O-methyltransferase (COMT) may be associated with treatment response in depression. We conducted a study on 119 patients with treatment-refractory depression admitted consecutively for electroconvulsive therapy (ECT). The COMT high/high genotype leads to a higher enzyme activity and thus lowers dopaminergic activity in the prefrontal cortex. In the present sample, those homozygous to high-active allele of COMT responded significantly more frequently to ECT.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Catecol O-Metiltransferasa
/
Regulación Enzimológica de la Expresión Génica
/
Trastorno Depresivo Mayor
/
Terapia Electroconvulsiva
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Pharmacogenomics J
Asunto de la revista:
BIOLOGIA MOLECULAR
/
FARMACOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Finlandia