Congenital cervical spinal cord lesions: pathogenesis, management, and outcome.
J Child Neurol
; 22(7): 874-9, 2007 Jul.
Article
en En
| MEDLINE
| ID: mdl-17715282
ABSTRACT
Three patients (2 boys) presented with nontraumatic congenital lesions of the spinal cord resulting in paralysis and contractures of their upper limbs from birth. Limited improvement occurred in all. Two survived. One patient required ventilation support after birth; his upper limbs had lower motor neuron flaccid paralysis, and his lower limbs evolved to pyramidal tract impairment. He died at 9 months of age with an intercurrent chest infection. The other 2 patients had lower motor neuron pathology in their upper limbs and normal lower limb function. One of these patients attained ambulation. All 3 patients retained normal higher mental function. Neuroimaging of the spinal cord from the most affected patient demonstrated atrophy of the cervical and high thoracic regions (C4-T3). Spinal neuroimaging results from the less affected patient were normal. Multidisciplinary management assisted these children to reach their full potential in a resource-poor setting. The etiology of focal pathology to the cervical region in these infants with congenital nontraumatic insults remains undefined, similar to the few cases in the literature. The diverse pathogeneses are hypothesized and the literature reviewed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Parálisis
/
Médula Espinal
/
Enfermedades de la Médula Espinal
Tipo de estudio:
Etiology_studies
Límite:
Child
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
J Child Neurol
Asunto de la revista:
NEUROLOGIA
/
PEDIATRIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Sudáfrica