Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients.
J Ren Nutr
; 17(5): 296-304, 2007 Sep.
Article
en En
| MEDLINE
| ID: mdl-17720098
ABSTRACT
OBJECTIVE:
Increased cardiovascular risk in hemodialysis patients may be related to augmented oxidative stress and inflammation, for which no proven beneficial therapies are available. STUDYDESIGN:
We examined the effects of gamma tocopherol and docosahexaenoic acid (DHA) administration on inflammation and oxidative stress markers in hemodialysis patients in a randomized, double-blinded, placebo-controlled, clinical trial. Active treatment consisted of capsules containing gamma tocopherol (308 mg) and DHA (800 mg).SETTING:
Outpatient dialysis center. PATIENTS Seventy maintenance hemodialysis patients. MAIN OUTCOMEMEASURES:
Plasma concentrations of interleukin-6 (IL-6) and protein carbonyl content were determined by enzyme-linked immunosorbant assay. C-reactive protein was measured by nephelometry. The F(2) isoprostanes were measured by gas chromatography-mass spectrometry. Erythrocyte DHA content was measured by gas chromatography.RESULTS:
Sixty-three patients were enrolled, and 57 completed the study. No serious adverse events were attributed to either active treatment or placebo. In the treatment group, but not in the placebo group, there were significant decreases in IL-6 (21.4 +/- 3.5 to 16.8 +/- 3.7 pg/mL), white blood cell (WBC) count (7.4 +/- 0.3 to 6.9 +/- 0.4 10(3)/microL), and neutrophil fraction of WBCs (4.8 +/- 0.3 to 4.4 +/- 0.3 10(3)/microL), at P < .05 for all. There were no significant changes in plasma concentrations of CRP, F(2) isoprostanes, or carbonyls in either group.CONCLUSION:
Thus, gamma tocopherol and DHA are well-tolerated and reduce selected biomarkers of inflammation in hemodialysis patients. Larger randomized, clinical trials will be required to determine if gamma tocopherol and DHA can reduce cardiovascular complications in hemodialysis patients.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Docosahexaenoicos
/
Diálisis Renal
/
Estrés Oxidativo
/
Gamma-Tocoferol
/
Inflamación
/
Fallo Renal Crónico
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Ren Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
NEFROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos