Frontal-subcortical circuitry and behavior.
Dialogues Clin Neurosci
; 9(2): 141-51, 2007.
Article
en En
| MEDLINE
| ID: mdl-17726913
ABSTRACT
The neuropsychiatric manifestations of neurodegenerative diseases are closely linked to neurocircuitry defects. Frontal-subcortical circuits, in particular, are effector mechanisms that allow the organism to act on its environment. In this paper, we present the three main frontal-subcortical circuits the dorsolateral prefrontal circuit allows the organization of information to facilitate a response; the anterior cingulate circuit is required for motivated behavior; and the orbitofrontal circuit allows the integration of limbic and emotional information into behavioral responses. Impaired executive functions, apathy, and impulsivity are hallmarks of frontal-subcortical circuit dysfunction. A variety of other neuropsychiatric disorders, such as Tourette's syndrome, Huntington's disease, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, schizophrenia, and mood disorders may result from disturbances that have a direct or indirect impact on the integrity or functioning of these loops.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encefalopatías
/
Corteza Prefrontal
/
Giro del Cíngulo
/
Trastornos Mentales
/
Vías Nerviosas
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Dialogues Clin Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Austria