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[Usefulness of recombinant human erythropoietin in cardiac surgery with autologous blood transfusion].
Takanashi, S; Kohama, M; Aoki, K; Furuta, S; Numata, K.
Afiliación
  • Takanashi S; Department of Surgery, Cardiovascular Institute Hospital, Tokyo, Japan.
Nihon Kyobu Geka Gakkai Zasshi ; 39(12): 2140-4, 1991 Dec.
Article en Ja | MEDLINE | ID: mdl-1774500
ABSTRACT
The efficacy and method of administration of recombinant human erythropoietin (EPO) in adult cardiac surgical patients when given preoperatively was evaluated. We used EPO intravenously (iv) with 40 mg ferric oxide for a total of consecutive 47 patients. The patients were divided into group A (n = 14; EPO 200 IU/kg iv 3 times a week from 3 weeks prior to surgery to 2 weeks after surgery, donation of 800 ml) and group B (n = 33; EPO 200 IU/kg iv everyday from 8 days prior to surgery to 2 weeks after surgery, donation of 400 ml). Control groups were group AO (n = 11; donation of 835 +/- 33 ml from 14.8 days prior to surgery) and group BO (n = 7; donation of 406 +/- 34 ml at 7.3 days prior to surgery). All the EPO-treated patients received no homologous blood transfusion while 2 of patients in group BO received some homologous blood transfusion. A hemoglobin change between pre-donation and surgery was +0.14 +/- 1.3 (g/dl) in group A, +0.04 +/- 1.0 (g/dl) in group B, -1.7 +/- 1.3 (g/dl) in group AO and -1.0 +/- 0.6 (g/dl) in group BO. In a comparison of post-surgical hemoglobin levels between group A and group B, we demonstrated that the level in group B, +2.1 +/- 1.8 (g/dl) was significantly higher than that in group A, +11.1 +/- 1.6 (g/dl) 2 weeks after surgery. There was no evidence to show an aggravation of anemia in the pre-surgical period in EPO-treated groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Transfusión de Sangre Autóloga / Eritropoyetina / Procedimientos Quirúrgicos Cardíacos / Anemia Límite: Humans Idioma: Ja Revista: Nihon Kyobu Geka Gakkai Zasshi Año: 1991 Tipo del documento: Article País de afiliación: Japón
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Transfusión de Sangre Autóloga / Eritropoyetina / Procedimientos Quirúrgicos Cardíacos / Anemia Límite: Humans Idioma: Ja Revista: Nihon Kyobu Geka Gakkai Zasshi Año: 1991 Tipo del documento: Article País de afiliación: Japón