Possible prognostic significance of p53 and Ki 67 in inverted sinonasal papilloma.
Coll Antropol
; 31(2): 545-9, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17847937
ABSTRACT
The aim of this study is to test the possible prognostic significance of p53 and Ki67 expression in inverted papilloma of the lateral nasal wall and adjacent sinuses regarding their malignant potential and recurrence. 49 biopsies of the lateral nasal wall and adjacent sinuses obtained from 41 patients from three hospitals were investigated. Immunohistochemically demonstrated p53 and Ki67 expression was measured and statistically evaluated. p53 immunoreactivity was demonstrated in most of papillomas with carcinomas but only in two benign papillomas, while Ki67 demonstrated stronger immunoreactivity in carcinomas and surrounding epithelium. Immunohistochemical staining of inverted sinonasal papillomas for p53 and Ki67 can give useful information concerning the existence of synchronous carcinoma and, in case of high Ki67, a hint toward possible recurrence.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de los Senos Paranasales
/
Proteína p53 Supresora de Tumor
/
Papiloma Invertido
/
Antígeno Ki-67
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Coll Antropol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Croacia