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Propionibacterium acnes: an under-appreciated cause of post-neurosurgical infection.
Nisbet, M; Briggs, S; Ellis-Pegler, R; Thomas, M; Holland, D.
Afiliación
  • Nisbet M; Infectious Disease Department, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand. mitzin@xtra.co.nz
J Antimicrob Chemother ; 60(5): 1097-103, 2007 Nov.
Article en En | MEDLINE | ID: mdl-17875606
BACKGROUND: Propionibacterium acnes is increasingly recognized as a cause of post-neurosurgical infection. This review of patients with P. acnes neurosurgical infection was carried out in order to determine clinical characteristics and outcomes in relation to duration of antimicrobial treatment. METHODS: We retrospectively reviewed the charts of consecutive patients with P. acnes isolated from neurosurgical specimens from 1 January 1999 to 30 June 2005. We defined P. acnes neurosurgical infection as isolation of P. acnes alone from a sterile neurosurgical site in a patient who clinically improved following treatment with an appropriate antibiotic. RESULTS: We identified 28 patients with definite P. acnes neurosurgical infection; median age 49 years (range 23-77); 15 (54%) male. All patients had prior neurosurgical procedures: 27 (96%) post-craniotomy. The median time from surgery to presentation was 54 days (range 12-1,578). Eighteen out of 28 (64%) patients who met the definition of neurosurgical infection had Gram-positive bacilli seen in at least one surgical specimen compared with only 2/56 (4%) patients who did not meet the definition (P < 0.0001). Intravenous benzyl penicillin +/- oral penicillin VK was the most common treatment. The median duration of antibiotic treatment for intracranial infection was 29 days. Five of nine patients who had extracranial bone-flap-associated infection had
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Propionibacterium acnes / Infección de la Herida Quirúrgica / Infecciones por Bacterias Grampositivas / Procedimientos Neuroquirúrgicos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Antimicrob Chemother Año: 2007 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Propionibacterium acnes / Infección de la Herida Quirúrgica / Infecciones por Bacterias Grampositivas / Procedimientos Neuroquirúrgicos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Antimicrob Chemother Año: 2007 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido