Synthesized esters of ferulic acid induce release of cytochrome c from rat testes mitochondria.
J Bioenerg Biomembr
; 40(1): 19-26, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-17899337
ABSTRACT
Ferulic acid plays a chemopreventive role in cancer by inducing tumor cells apoptosis. As mitochondria play a key role in the induction of apoptosis in many cells types, here we investigate the mitochondrial permeability transition (MPT) and the release of cytochrome c induced by ferulic acid and its esters in rat testes mitochondria, in TM-3 and MLTC-1 cells. While ferulic acid, but not its esters, induced MPT and cytochrome c release in rat testes isolated mitochondria, in TM-3 cells we found that both ferulic acid and its esters induced cytochrome c release from mitochondria in a dose-dependent manner, suggesting a potential target of these compounds in the induction of cell apoptosis. The apoptosis induced by ferulic acid is therefore associated with the mitochondrial pathway involving cytochrome c release and caspase-3 activation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Testículo
/
Apoptosis
/
Ácidos Cumáricos
/
Citocromos c
/
Caspasa 3
/
Mitocondrias
Límite:
Animals
Idioma:
En
Revista:
J Bioenerg Biomembr
Año:
2008
Tipo del documento:
Article
País de afiliación:
Italia