Emerging roles of ADAM and ADAMTS metalloproteinases in cancer.
Biochimie
; 90(2): 369-79, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-17920749
ABSTRACT
A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins that share the metalloproteinase domain with matrix metalloproteinases (MMPs). Among this family, structural features distinguish the membrane-anchored ADAMs and the secreted ADAMs with thrombospondin motifs referred to as ADAMTSs. By acting on a large panel of membrane-associated and extracellular substrates, they control several cell functions such as adhesion, fusion, migration and proliferation. The current review addresses the contribution of these proteinases in the positive and negative regulation of cancer progression as mainly mediated by the regulation of growth factor activities and integrin functions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas ADAM
/
Neoplasias
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Biochimie
Año:
2008
Tipo del documento:
Article
País de afiliación:
Bélgica