Complex dosing schedules for continuous intrathecal baclofen infusion.
Pediatr Neurol
; 37(5): 354-9, 2007 Nov.
Article
en En
| MEDLINE
| ID: mdl-17950422
ABSTRACT
The objective of the present study was to understand the clinical reasons for changes from simple continuous to complex (flex) dosing for tone reduction in individuals receiving intrathecal baclofen. Methodology was a retrospective chart review study of 164 individuals (95 male, 69 female) at a multi-specialty children's hospital who were followed for at least 1 year for intrathecal baclofen management. Eighty-two persons were in the simple continuous only group and 82 also were on complex schedules at least once during the follow-up period. Mean age at most recent follow-up was 18 years and 0 months (median, 15 years and 8 months; standard deviation, 8 years and 0 months; range, 6-45). The top three clinical reasons for switching dosing method were to (1) optimize intrathecal baclofen effect, (2) treat predictable daily tone variation, and (3) manage signs and symptoms of intrathecal baclofen withdrawal or underdelivery. In both groups, 90% of individuals had cerebral palsy, and mean baseline leg Ashworth scores were the same in both groups (mean, 3.7; standard deviation, 0.7). Mean total daily dose at chart review was higher in complex dosing (429.3 vs 211.9 microg/day), as was mean follow-up time (4.8 vs 3.9 years). Case examples are presented.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Baclofeno
/
Inyecciones Espinales
/
Parálisis Cerebral
/
Relajantes Musculares Centrales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Pediatr Neurol
Asunto de la revista:
NEUROLOGIA
/
PEDIATRIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos