Risk factors of arterial hypertension after renal transplantation.

ABSTRACT

Arterial hypertension often present after kidney transplantation is of multifactorial origin. The aim of this study was to determine the role of donor and recipient factors in the development of hypertension after renal transplantation. We retrospectively analyzed the data of 280 patients transplanted between 1985 and 2005, who still had functioning grafts at 1 year after transplantation. We recorded donor and recipient parameters. One hundred eighty-seven patients (66.8%) were hypertensive. Upon multivariate analysis of recipient factors, pretransplant hypertension (odds ratio) [OR] 8.5, 95% confidence interval [CI] 4.5 to 16.1); serum creatinine level > 130 micromol/L at 6 months (OR 2.5, 95% CI 1.3 to 4,7), male gender (OR 2.02, 95% CI 1.2 to 3.4), and chronic rejection (OR 2.4, 95% CI 1.2 to 4.7) were independent predisposing factors. Among donor factors, age was significantly associated with arterial hypertension upon univariate analysis. In conclusion, recipient factors, especially pretransplant hypertension, contribute to the disorder in renal transplant patients.