[Daily interruption of sedation in intensive care unit patients with renal impairment: remifentanil-midazolam compared to fentanyl-midazolam]. / Arrêt journalier de la sédation en réanimation chez l'insuffisant rénal: rémifentanil-midazolam versus fentanyl-midazolam.
Ann Fr Anesth Reanim
; 26(12): 1041-4, 2007 Dec.
Article
en Fr
| MEDLINE
| ID: mdl-17988824
ABSTRACT
OBJECTIVE:
We compared extubation time following daily interruption of sedation in intensive care unit patients with renal impairment with two sedation regimes remifentanil-midazolam and fentanyl-midazolam. STUDYDESIGN:
Prospective, randomized double-blind trial. PATIENTS ANDMETHODS:
Patients with renal impairment needing mechanical ventilation for more than 48 hours. Two groups remifentanil (R) and fentanyl (F), Infusion rates were titrated to achieve the desired Ramsay score. The two groups received midazolam (2.5 mg then 0.1 mg/kg/h).RESULTS:
Nineteen patients were included. Patient's characteristics, mean sedation time and sedation quality were comparable. Extubation time was significantly shorter in R group (1480+/-980 versus 2880+/-1280 min, P=0.04). Weaning time was also shorter in R group (220+/-164 versus 720+/-480 min). Agitation on weaning was comparable in the two groups. Group R received significantly more morphine than group F after interruption of sedation.CONCLUSION:
Daily interruption of sedation with remifentanil is associated with shorter weaning and extubation time in patients with renal impairment. However further studies are necessary to determine if this issue is associated with lower rate of ventilation induced complications.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Midazolam
/
Fentanilo
/
Sedación Consciente
/
Anestésicos Combinados
/
Cuidados Críticos
/
Insuficiencia Renal
/
Hipnóticos y Sedantes
/
Unidades de Cuidados Intensivos
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Fr
Revista:
Ann Fr Anesth Reanim
Año:
2007
Tipo del documento:
Article
País de afiliación:
Túnez