Bayesian estimation for molecular profile reconstruction in proteomics based on liquid chromatography and mass spectrometry.
Annu Int Conf IEEE Eng Med Biol Soc
; 2007: 5980-3, 2007.
Article
en En
| MEDLINE
| ID: mdl-18003376
ABSTRACT
There is a need to precisely measure concentration of proteins in biological substance for early diagnosis of disease or knowledge of fundamental biological processes. Many apparatus have been proposed, and now data processing methods have to be investigated. This paper focuses on data processing of proteomic experiments combining nano liquid chromatography and mass spectrometry. Experimental fluctuations of this process raise an interest for robust methods. Consequently, we propose a model of this acquisition system and a probabilistic Bayesian method to estimate the proteins' concentrations and system parameters.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espectrometría de Masas
/
Mapeo Peptídico
/
Reconocimiento de Normas Patrones Automatizadas
/
Cromatografía Liquida
/
Proteoma
/
Perfilación de la Expresión Génica
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
/
Screening_studies
Idioma:
En
Revista:
Annu Int Conf IEEE Eng Med Biol Soc
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA