Population pharmacokinetics of micafungin in adult patients.
Diagn Microbiol Infect Dis
; 60(3): 329-31, 2008 Mar.
Article
en En
| MEDLINE
| ID: mdl-18024052
ABSTRACT
We performed population pharmacokinetic analysis of micafungin in adult patients treated with doses between 12.5 and 200 mg/day. Our analysis identified a breakpoint patient weight of 66.3 kg above which serum clearance increased by approximately 50%. Patients with weight >66.3 kg may need larger doses to achieve similar exposures to those <66.3 kg. However, the clinical implications are still unknown.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Equinocandinas
/
Lipoproteínas
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Diagn Microbiol Infect Dis
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos