POEMS syndrome: an Italian case with diagnostic and therapeutic implications.
Ann Ital Med Int
; 6(4): 416-9, 1991.
Article
en En
| MEDLINE
| ID: mdl-1804287
A young Italian patient with a multisystem disorder and a solitary osteosclerotic bone lesion is described. His clinicopathological situation involved sensory-motor polyneuropathy, organomegaly, endocrine dysfunction, skin alterations, edema of the lower limbs and generalized lymphadenopathy. These features were consistent with the diagnosis of POEMS syndrome, reported primarily in Japanese patients. M components were not found in this patient's serum or urine. Bone marrow biopsy showed only a slight plasma cell infiltrate; histological study of the sural nerve evidenced a mixture of both axonal degeneration and segmental demyelinization. Lymph node biopsy revealed peculiar pathological changes resembling those of type II Castleman-like disease. A wide bone defect with osteosclerotic margins and trabeculation was evidenced in the right ilium. The relationship of these findings to plasma cell dyscrasias is discussed. After prednisone and local radiotherapy failed, the patient was treated with human recombinant interferon for 18 months. After three months of therapy he has experienced remarkable improvement of his neurological symptoms and almost complete recovery of organomegaly and lymphadenopathy. These improvements have continued to the present.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome POEMS
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Ann Ital Med Int
Asunto de la revista:
MEDICINA INTERNA
Año:
1991
Tipo del documento:
Article
Pais de publicación:
Italia